| Day One | ||||
| Tuesday 18 September 2012 | ||||
| Dinamo Zagreb | 0-2 | Porto | 19:45 | |
| PSG | 4-1 | Dynamo Kyiv | 19:45 | |
| Montpellier | 1-2 | Arsenal | 19:45 | |
| Olympiakos | 1-2 | Schalke | 19:45 | |
| Malaga | 3-0 | Zenit | 19:45 | |
| Milan | 0-0 | Anderlecht | 19:45 | |
| Dortmund | 1-0 | Ajax | 19:45 | |
| Real Madrid | 3-2 | Manchester City | 19:45 | |
| Day Two | ||||
| Wednesday 19 September 2012 | ||||
| Shakhtar Donetsk | 2-0 | Nordsjaelland | 19:45 | |
| Chelsea | 2-2 | Juventus | 19:45 | |
| Lille | 1-3 | Bate Borisov | 19:45 | |
| Bayern Munich | 2-1 | Valencia | 19:45 | |
| Barcelona | 3-2 | Spartak Moscow | 19:45 | |
| Celtic | 0-0 | Benfica | 19:45 | |
| Manchester United | 1-0 | Galatasaray | 19:45 | |
| Braga | 0-2 | Cluj | 19:45 | |
| Day Three | ||||
| Tuesday 2 October 2012 | ||||
| Nordsjaelland | 0-4 | Chelsea | 19:45 | |
| Juventus | 1-1 | Shakhtar Donetsk | 19:45 | |
| Bate Borisov 3 | 3-1 | Bayern Munich | 19:45 | |
| Valencia | 2-0 | Lille | 19:45 | |
| Spartak Moscow | 2-3 | Celtic | 17:00 | |
| Benfica | 0-2 | Barcelona | 19:45 | |
| Cluj | 1-2 | Manchester United | 19:45 | |
| Galatasaray | 0-2 | Braga | 19:45 | |
| Day Four | ||||
| Wednesday 3 October 2012 | ||||
| Dynamo Kyiv | 2-0 | Dinamo Zagreb | 19:45 | |
| Porto | 1-0 | PSG | 19:45 | |
| Arsenal | 3-1 | Olympiakos | 19:45 | |
| Schalke | 2-2 | Montpellier | 19:45 | |
| Zenit St Petersburg | 2-3 | Milan | 17:00 | |
| Anderlecht | 0-3 | Malaga | 19:45 | |
| Ajax | 1-4 | Real Madrid | 19:45 | |
| Manchester City | 1-1 | Dortmund | 19:45 | |
| Day Five | ||||
| Tuesday 23 October 2012 | ||||
| Nordsjaelland | 1-1 | Juventus | 19:45 | |
| Shakhtar Donetsk | 2-1 | Chelsea | 19:45 | |
| Bate Borisov | 0-3 | Valencia | 19:45 | |
| Lille | 0-1 | Bayern Munich | 19:45 | |
| Spartak Moscow | 2-1 | Benfica | 17:00 | |
| Barcelona | 2-1 | Celtic | 19:45 | |
| Galatasaray | 1-1 | Cluj | 19:45 | |
| Manchester United | 3-2 | Braga | 19:45 | |
| Day Six | ||||
| Wednesday 24 October 2012 | ||||
| Dinamo Zagreb | 0-2 | PSG | 19:45 | |
| Porto | 3-2 | Dynamo Kyiv | 19:45 | |
| Arsenal | 0-2 | Schalke | 19:45 | |
| Montpellier | 1-2 | Olympiakos | 19:45 | |
| Zenit St Petersburg | 1-0 | Anderlecht | 17:00 | |
| Malaga | 0-1 | Milan | 19:45 | |
| Ajax | 3-1 | Manchester City | 19:45 | |
| Dortmund | 2-1 | Real Madrid | 19:45 | |
| Day Seven | ||||
| Tuesday 6 November 2012 | ||||
| Dynamo Kyiv | 0-0 | Porto | 19:45 | |
| PSG | 4-0 | Dinamo Zagreb | 19:45 | |
| Olympiakos | 3-1 | Montpellier | 19:45 | |
| Schalke | 2-2 | Arsenal | 19:45 | |
| Milan | 1-1 | Malaga | 19:45 | |
| Anderlecht | 1-0 | Zenit St Petersburg | 19:45 | |
| Manchester City | 2-2 | Ajax | 19:45 | |
| Real Madrid | 2-2 | Dortmund | 19:45 | |
| Day Eight | ||||
| Wednesday 7 November 2012 | ||||
| Chelsea | 3-2 | Shakhtar Donetsk | 19:45 | |
| Juventus | 4-0 | Nordsjalland | 19:45 | |
| Bayern Munich | 6-1 | Lille | 19:45 | |
| Valencia | 4-2 | Bate Borisov | 19:45 | |
| Benfica | 2-0 | Spartak Moscow | 19:45 | |
| Celtic | 2-1 | Barcelona | 19:45 | |
| Braga | 1-3 | Manchester United | 19:45 | |
| Cluj | 1-3 | Galatasaray | 19:45 | |
| Day Nine | ||||
| Tuesday 20 November 2012 | ||||
| Nordsjalland | 2-5 | Shakhtar Donetsk | 19:45 | |
| Juventus | 3-0 | Chelsea | 19:45 | |
| Bate Borisov | 0-2 | Lille | 17:00 | |
| Valencia | 1-1 | Bayern Munich | 19:45 | |
| Spartak Moscow | 0-3 | Barcelona | 17:00 | |
| Benfica | 2-1 | Celtic | 19:45 | |
| Cluj | 3-1 | Braga | 19:45 | |
| Galatasaray | 1-0 | Manchester United | 19:45 | |
| Day Ten | ||||
| Wednesday 21 November 2012 | ||||
| Dynamo Kyiv | 0-2 | PSG | 19:45 | |
| Porto | 3-0 | Dinamo Zagreb | 19:45 | |
| Arsenal | 2-0 | Montpellier | 19:45 | |
| Schalke | 1-0 | Olympiakos | 19:45 | |
| Zenit St Petersburg | 2-2 | Malaga | 17:00 | |
| Anderlecht | 1-3 | Milan | 19:45 | |
| Ajax | 1-4 | Dortmund | 19:45 | |
| Manchester City | 1-1 | Real Madrid | 19:45 | |
| Day Eleven | ||||
| Tuesday 4 December 2012 | ||||
| Dinamo Zagreb | 1-1 | Dynamo Kyiv | 19:45 | |
| PSG | 2-1 | Porto | 19:45 | |
| Montpellier | 1-1 | Schalke | 19:45 | |
| Olympiakos | 2-1 | Arsenal | 19:45 | |
| Milan | 0-1 | Zenit St Petersburg | 19:45 | |
| Malaga | 2-2 | Anderlecht | 19:45 | |
| Dortmund | 1-0 | Manchester City | 19:45 | |
| Real Madrid | 4-1 | Ajax | 19:45 | |
| Day Twelve | ||||
| Wednesday 5 December 2012 | ||||
| Chelsea | 6-1 | Nordsjalland | 19:45 | |
| Shakhtar Donetsk | 0-1 | Juventus | 19:45 | |
| Bayern Munich | 4-1 | Bate Borisov | 19:45 | |
| Lille | 0-1 | Valencia | 19:45 | |
| Barcelona | 0-0 | Benfica | 19:45 | |
| Celtic | 2-1 | Spartak Moscow | 19:45 | |
| Braga | 1-2 | Galatasaray | 19:45 | |
| Manchester United | 0-1 | Cluj | 19:45 | |
| Last 16 | ||||
| Tuesday 12 February 2013 | ||||
| Celtic | 0-3 | Juventus | 19:45 | |
| Valencia | 1-2 | PSG | 19:45 | |
| Wednesday 13 February 2013 | ||||
| Real Madrid | 1-1 | Manchester United | 19:45 | |
| Shakhtar Donetsk | 2-2 | Dortmund | 19:45 | |
| Last 16 | ||||
| Tuesday 19 February 2013 | ||||
| Arsenal | 1-3 | Bayern Munich | 19:45 | |
| Porto | 1-0 | Malaga | 19:45 | |
| Wednesday 20 February 2013 | ||||
| Milan | 2-0 | Barcelona | 19:45 | |
| Galatasaray | 1-1 | Schalke | 19:45 | |
| Last 16 | ||||
| Tuesday 5 March 2013 | ||||
| Dortmund | 3-0 | Shakhtar Donetsk | 19:45 | |
| Manchester United | 1-2 | Real Madrid | 19:45 | |
| Wednesday 6 March 2013 | ||||
| Juventus | 2-0 | Celtic | 19:45 | |
| PSG | 1-1 | Valencia | 19:45 | |
| Last 16 | ||||
| Tuesday 12 March 2013 | ||||
| Schalke | 2-3 | Galatasaray | 19:45 | |
| Barcelona | 4-0 | Milan | 19:45 | |
| Wednesday 13 March 2013 | ||||
| Bayern Munich * | 0-2 | Arsenal | 19:45 | |
| Malaga | 2-0 | Porto | 19:45 | |
| Quarter Finals | ||||
| Tuesday 2 April 2013 | ||||
| PSG | 2-2 | Barcelona | 19:45 | |
| Bayern Munich | 2-0 | Juventus | 19:45 | |
| Wednesday 3 April 2013 | ||||
| Malaga | 0-0 | Dortmund | 19:45 | |
| Real Madrid | 3-0 | Galatasaray | 19:45 | |
| Quarter Finals | ||||
| Tuesday 9 April 2013 | ||||
| Dortmund | 3-2 | Malaga | 19:45 | |
| Galatasaray | 3-2 | Real Madrid | 19:45 | |
| Wednesday 10 April 2013 | ||||
| Barcelona | 1-1 | PSG | 19:45 | |
| Juventus | 0-2 | Bayern Munich | 19:45 | |
| Semi Finals | ||||
| Tuesday 23 April 2013 | ||||
| Bayern Munich | 4-0 | Barcelona | 19:45 | |
| Wednesday 24 April 2013 | ||||
| Dortmund | 4-1 | Real Madrid | 19:45 | |
| Tuesday 30 April 2013 | ||||
| Real Madrid | 2-0 | Dortmund | 19:45 | |
| Wednesday 1 May 2013 | ||||
| Barcelona | 0-3 | Bayern Munich | 19:45 | |
| Final | ||||
| Saturday 25 May 2013 | ||||
| Dortmund | 1-2 | Bayern Munich | 19:45 | |
* = win on away goals