| Tuesday 13 September 2011 | |||
| Chelsea | 2-0 | Leverkusen | 19:45 |
| Genk | 0-0 | Valencia | 19:45 |
| Dortmund | 1-1 | Arsenal | 19:45 |
| Olympiakos | 0-1 | Marseille | 19:45 |
| Apoel Nicosia | 2-1 | Zenit St Petersburg | 19:45 |
| Porto | 2-1 | Shakhtar Donetsk | 19:45 |
| Barcelona | 2-2 | Milan | 19:45 |
| Plzen | 1-1 | Bate Borisov | 19:45 |
| Wednesday 14 September 2011 | |||
| Manchester City | 1-1 | Napoli | 19:45 |
| Villarreal | 0-2 | Bayern Munich | 19:45 |
| Inter | 0-1 | Trabzinspor | 19:45 |
| Lille | 2-2 | CSKA Moscow | 19:45 |
| Benfica | 1-1 | Manchester United | 19:45 |
| Basel | 2-1 | Otelul Galati | 19:45 |
| Ajax | 0-0 | Lyon | 19:45 |
| Dinamo Zagreb | 1-0 | Real Madrid | 19:45 |
| Tuesday 27 September 2011 | |||
| CSKA Moscow | 2-3 | Inter | 17:00 |
| Bayern Munich | 2-0 | Manchester City | 19:45 |
| Napoli | 2-0 | Villarreal | 19:45 |
| Trabzonspor | 1-1 | Lille | 19:45 |
| Manchester United | 3-3 | Basel | 19:45 |
| Otelul Galati | 0-1 | Benfica | 19:45 |
| Lyon | 2-0 | Dinamo Zagreb | 19:45 |
| Real Madrid | 3-0 | Ajax | 19:45 |
| Wednesday 28 September 2011 | |||
| Zenit St Petersburg | 3-1 | Porto | 17:00 |
| Leverkusen | 2-0 | Genk | 19:45 |
| Valencia | 1-1 | Chelsea | 19:45 |
| Marseille | 3-0 | Dortmund | 19:45 |
| Arsenal | 2-1 | Olympiakos | 19:45 |
| Shakhtar Donetsk | 1-1 | Apoel Nicosia | 19:45 |
| Milan | 2-0 | Viktoria Plzen | 19:45 |
| Bate Borisov | 0-5 | Barcelona | 19:45 |
| Tuesday 18 October 2011 | |||
| Napoli | 1-1 | Bayern Munich | 19:45 |
| Manchester City | 2-1 | Villarreal | 19:45 |
| CSKA Moscow | 3-0 | Trabzonspor | - |
| Lille | 0-1 | Inter | 19:45 |
| Otelul Galati | 0-2 | Manchester United | 19:45 |
| Basel | 0-2 | Benfica | 19:45 |
| Real Madrid | 4-0 | Lyon | 19:45 |
| Dinamo Zagreb | 0-2 | Ajax | 19:45 |
| Wednesday 19 October 2011 | |||
| Leverkusen | 2-1 | Valencia | 19:45 |
| Chelsea | 5-0 | Genk | 19:45 |
| Marseille | 0-1 | Arsenal | 19:45 |
| Olympiakos | 3-1 | Dortmund | 19:45 |
| Shakhtar Donetsk | 2-2 | Zenit St Petersburg | 19:45 |
| Porto | 1-1 | Apoel Nicosia | 19:45 |
| Milan | 2-0 | Bate Borisov | 19:45 |
| Barcelona | 2-0 | Viktoria Plzen | 19:45 |
| Tuesday 1 November 2011 | |||
| Genk | 1-1 | Chelsea | 19:45 |
| Valencia | 3-1 | Leverkusen | 19:45 |
| Arsenal | 0-0 | Marseille | 19:45 |
| Dortmund | 1-0 | Olympiakos | 19:45 |
| Zenit St Petersburg | 1-0 | Shakhtar Donetsk | 19:45 |
| Apoel Nicosia | 2-1 | Porto | 19:45 |
| Bate Borisov | 1-1 | Milan | 17:00 |
| Viktoria Plzen | 0-4 | Barcelona | 19:45 |
| Wednesday 2 November 2011 | |||
| Bayern Munich | 3-2 | Napoli | 19:45 |
| Villarreal | 0-3 | Manchester City | 19:45 |
| Inter | 2-1 | Lille | 19:45 |
| Trabzonspor | 0-0 | CSKA Moscow | 19:45 |
| Benfica | 1-1 | Basel | 19:45 |
| Manchester United | 2-0 | Otelul Galati | 19:45 |
| Ajax | 4-0 | Dinamo Zagreb | 19:45 |
| Lyon | 0-2 | Real Madrid | 19:45 |
| Tuesday 22 November 2011 | |||
| CSKA Moscow | 0-2 | Lille | 17:00 |
| Bayern Munich | 3-1 | Villarreal | 19:45 |
| Napoli | 2-1 | Manchester City | 19:45 |
| Trabzonspor | 1-1 | Inter | 19:45 |
| Manchester United | 2-2 | Benfica | 19:45 |
| Otelul Galati | 2-3 | Basel | 19:45 |
| Lyon | 0-0 | Ajax | 19:45 |
| Real Madrid | 6-2 | Dinamo Zagreb | 19:45 |
| Wednesday 23 November 2011 | |||
| Zenit St Petersburg | 0-0 | APOEL Nicosea | 17:00 |
| BATE Borisov | 0-1 | Viktoria Plzen | 19:45 |
| Valencia | 7-0 | Genk | 19:45 |
| Leverkusen | 2-1 | Chelsea | 19:45 |
| Marseille | 0-1 | Olympiakos | 19:45 |
| Arsenal | 2-1 | Dortmund | 19:45 |
| Shakhtar Donetsk | 0-2 | Porto | 19:45 |
| Milan | 2-3 | Barcelona | 19:45 |
| Tuesday 6 December 2011 | |||
| Chelsea | 3-0 | Valencia | 19:45 |
| Genk | 1-1 | Leverkusen | 19:45 |
| Dortmund | 2-3 | Marseille | 19:45 |
| Olympiakos | 3-1 | Arsenal | 19:45 |
| APOEL Nicosia | 0-2 | Shakhtar Donetsk | 19:45 |
| Porto | 0-0 | Zenit St Petersburg | 19:45 |
| Barcelona | 4-0 | Bate Borisov | 19:45 |
| Viktoria Plzen | 2-2 | Milan | 19:45 |
| Wednesday 7 December 2011 | |||
| Manchester City | 2-0 | Bayern Munich | 19:45 |
| Villarreal | 0-2 | Napoli | 19:45 |
| Inter | 1-2 | CSKA Moscow | 19:45 |
| Lille | 0-0 | Trabzonspor | 19:45 |
| Benfica | 1-0 | Otelul Galati | 19:45 |
| Basel | 2-1 | Manchester United | 19:45 |
| Ajax | 0-3 | Real Madrid | 19:45 |
| Dinamo Zagreb | 1-7 | Lyon | 19:45 |
| Tuesday 14 February 2012 | |||
| Lyon | 1-0 | APOEL Nicosia | 19:45 |
| Leverkusen | 1-3 | Barcelona | 19:45 |
| Wednesday 15 February 2012 | |||
| Zenit St Petersburg | 3-2 | Benfica | 17:00 |
| Milan | 4-0 | Arsenal | 19:45 |
| Tuesday 21 February 2012 | |||
| CSKA Moscow | 1-1 | Real Madrid | 17:00 |
| Napoli | 3-1 | Chelsea | 19:45 |
| Wednesday 22 February 2012 | |||
| Basel | 1-0 | Bayern Munich | 19:45 |
| Marseille | 1-0 | Inter | 19:45 |
| Tuesday 6 March 2012 | |||
| Arsenal | 3-0 | Milan | 19:45 |
| Benfica | 2-0 | Zenit St Petersburg | 19:45 |
| Wednesday 7 March 2012 | |||
| APOEL Nicosia ** | 1-0 | Lyon | 19:45 |
| Barcelona | 7-1 | Leverkusen | 19:45 |
| Tuesday 13 March 2012 | |||
| Bayern Munich | 7-0 | Basel | 19:45 |
| Inter | 2-1* | Marseille | 19:45 |
| Wednesday 14 March 2012 | |||
| Chelsea | 4-1 | Napoli | 19:45 |
| Real Madrid | 4-1 | CSKA Moscow | 19:45 |
| Tuesday 27 March 2012 | |||
| APOEL Nicosia | 0-3 | Real Madrid | 19:45 |
| Benfica | 0-1 | Chelsea | 19:45 |
| Wednesday 28 March 2012 | |||
| Marseille | 0-2 | Bayern Munich | 19:45 |
| Milan | 0-0 | Barcelona | 19:45 |
| Tuesday 3 April 2012 | |||
| Bayern Munich | 2-0 | Marseille | 19:45 |
| Barcelona | 3-1 | Milan | 19:45 |
| Wednesday 4 April 2012 | |||
| Real Madrid | 5-2 | APOEL Nicosia | 19:45 |
| Chelsea | 3-1 | Benfica | 19:45 |
| Tuesday 17 April 2012 | |||
| Bayern Munich | 2-1 | Real Madrid | 19:45 |
| Wednesday 18 April 2012 | |||
| Chelsea | 1-0 | Barcelona | 19:45 |
| Tuesday 24 April 2012 | |||
| Barcelona | 2-2 | Chelsea | 19:45 |
| Wednesday 25 April 2012 | |||
| Real Madrid | 3-3 ** | Bayern Munich | 19:45 |
| Saturday 19 May 2012 | |||
| Bayern Munich | 1-1 ** | Chelsea | 19:45 |
| * = win on away goals | |||
| ** = win on penalties | |||